The short version of Cardarine fits in a sentence. The long version — which is the one that helps — is below.
Reviewed 2026-02-14. Anything still debated is marked as such rather than presented as settled.
Cardarine is a common name for GW501516, an investigational compound developed in the 1990s for metabolic conditions. It acts as an agonist at peroxisome proliferator-activated receptor delta, a nuclear receptor involved in lipid and energy metabolism. The compound is frequently mislabeled as a selective androgen receptor modulator, or SARM, but its molecular target is different. GW501516 reached early clinical testing before development was discontinued. It has no approved therapeutic use in any country. The name cardarine is not a formal international nonproprietary name.
Regulatory treatment varies, but cardarine is not approved as a medicine. Sports authorities list GW501516 as a prohibited substance, and it is banned at all times under the World Anti-Doping Agency code. Many countries restrict sales for human consumption, while online vendors market it as a research chemical. Such products may lack purity data, and their actual contents can differ from the label. Purchasing or possessing cardarine may carry legal consequences depending on jurisdiction. The compound is not a dietary supplement ingredient in regulated markets.
Clinical development stopped after rodent studies showed tumors at multiple sites. Whether those findings predict human cancer risk remains an open question, but they led sponsors to discontinue programs. Human safety data are limited to small, short-term studies that were not designed to assess cancer risk. Reported effects in those studies included changes in blood lipids, but the evidence is insufficient for medical use. Long-term consequences of nonmedical use are not well characterized. Questions about dose, duration, and individual susceptibility remain unresolved.
Cardarine is the common name for GW501516, a synthetic compound studied as a peroxisome proliferator-activated receptor delta agonist. Researchers developed it to explore treatments for lipid disorders and metabolic conditions. It is not an approved medicine in any country. Early clinical work examined changes in HDL cholesterol and triglycerides, but development was discontinued after animal studies raised concerns about cancer. The compound remains available as a research chemical and appears in discussions of performance enhancement.
At the molecular level, GW501516 binds and activates PPARδ, a nuclear receptor that regulates transcription. Activation shifts expression of genes involved in fatty acid oxidation, energy expenditure, and lipid transport in skeletal muscle and liver. Animal studies report increased endurance and altered lipid profiles after exposure. Human data are limited to small trials and do not establish long-term safety or efficacy. PPARδ also has roles in cell proliferation, so the relationship between activation and cancer risk remains an open question.
| Property | Value | Notes |
|---|---|---|
| Common synonyms | GW501516; GW-1516; endurobol | GW501516 is the research code |
| Drug class | PPARδ agonist | Not a selective androgen receptor modulator |
| Molecular formula | C21H18F3NO3S2 | Established chemical formula |
| Molar mass | 453.5 g/mol | Calculated from the formula |
| Regulatory status | Prohibited in sport; not approved as medicine | Status varies by country |
Clinical: International assessment of diagnostics and therapy with the aim of improving clinical understanding and treatment procedures. Clinical-translational: Analysis of the significance of plasma and urine steroid profiles / liquid biopsy with the aim of identifying suitable tumor markers. Experimental: Identification of immunohistochemical characteristics and DNA sequencing with the aim of identifying drugable targets, i.e., targets for the drug treatment of tumor cells. This should ensure that healthy cells are spared from the drug as much as possible.
== See also == Breast hypertrophy – Rare human disease Male bra – Pieces of clothing that fit tightly around the skinPages displaying short descriptions of redirect targets Male lactation – Production of milk in male mammals Mammoplasia – Normal or spontaneous enlargement of breasts
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. CREST syndrome is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension.
Sources: en.wikipedia.org
== Causes == Acute periostitis is due to infection, characterized by diffuse formation of pus, severe pain, and constitutional symptoms, and usually results in necrosis. It can be caused by excessive physical activity as well, as in the case of medial tibial stress syndrome (also referred to as tibial periostalgia, soleus periostalgia, or shin splints). Congenital infection with syphilis can also cause periostitis in newborn infants. Hypertrophic osteoarthropathy can also cause periostitis.
If it's a legitimate rape, the female body has ways to try to shut the whole thing down." In 2017, Shaw had a supporting role as Gail Hurley in the feature film Stronger, which was directed by David Gordon Green, and starred Jake Gyllenhaal as 2013 Boston Marathon bombing survivor Jeff Bauman. In 2019, it was reported that Shaw is attached to direct an adaption of the Katherine Faw Morris novel Ultraluminous, produced by Steven Soderbergh. In 2020, numerous announcements were made regarding projects Shaw is attached to: she is reported to be writer and executive producer of an HBO series adapting the 1978 Judy Blume novel Wifey, and will direct the first episode; she is reportedly to star in Kill Switch, a film to be directed by Soderbergh; and she is attached to direct an adaption of T Kira Madden's memoir Long Live the Tribe of Fatherless Girls. She is also set to direct a film adaptation of the comic 4 Kids Walk Into a Bank.
Twenty-two radioisotopes of plutonium have been characterized, from 226Pu to 247Pu. The longest-lived are 244Pu, with a half-life of 80.8 million years; 242Pu, with a half-life of 373,300 years; and 239Pu, with a half-life of 24,110 years. All other isotopes have half-lives of less than 7,000 years. This element also has eight metastable states, though all have half-lives less than a second. 244Pu has been found in interstellar space and it has the longest half-life of any non-primordial radioisotope. The main decay modes of isotopes with mass numbers lower than the most stable isotope, 244Pu, are spontaneous fission and alpha emission, mostly forming uranium (92 protons) and neptunium (93 protons) isotopes as decay products (neglecting the wide range of daughter nuclei created by fission processes). The main decay mode for isotopes heavier than 244Pu, along with 241Pu and 243Pu, is beta emission, forming americium isotopes (95 protons). Plutonium-241 is the parent isotope of the neptunium series, decaying to americium-241 via beta emission. Plutonium-238 and 239 are the most widely synthesized isotopes. 239Pu is synthesized via the following reaction using uranium (U) and neutrons (n) via beta decay (β−) with neptunium (Np) as an intermediate:
== Diagnostic advantages == Due to PCT's variance between microbial infections and healthy individuals, procalcitonin has become a marker to improve identification of bacterial infection and guide antibiotic therapy. The table below is a summary from Schuetz, Albrich, and Mueller, summarizing the current data of selected, relevant studies investigating PCT in different types of infections. Legend: ✓ = Moderate evidence in favor of PCT ✓✓ = Good evidence in favor of PCT ✓✓✓ = Strong evidence in favor of PCT ~ = Evidence in favor or against the use of PCT, or still undefined
Sources: en.wikipedia.org
No. Cardarine is GW501516, a PPARδ agonist, while SARMs act on androgen receptors. The two classes are often grouped in informal discussions despite different mechanisms.
No. It has no approved medical indication in any country. Regulatory agencies have not cleared it for treatment or prevention of any condition.
Early clinical work stopped after rodent carcinogenicity findings. Those animal results raised concerns about long-term human risk, although direct human evidence is lacking. The human relevance of the tumors remains an open scientific question.
Cardarine is a common name for the investigational compound GW501516. It acts as a PPARδ agonist and is not approved for human use. It is prohibited in sport.